G
★
← Back to ranking growth.
Full review
Full ranking →
Ranked #8 of 15 Contains a prostaglandin analogue

GrandeLASH-MD

Enormously popular, genuinely effective, and built on isopropyl cloprostenate — the analogue named most often in reports of eyelid darkening and periorbital fat loss. GrandeLASH-MD is the clearest illustration of why this ranking weights safety at all.

Tested by the Growth Lash Serum panel · 12-week trial · Last reviewed 13 August 2026 · How we test

Price
£65
Size
2 ml
Cost / month
~£25
Type
Growth serum
Compare all 15 → Read the verdict
GrandeLASH-MD bottle
Growth overall score
Prostaglandin analogue: Isopropyl Cloprostenate
7.6
/ 10

Score breakdown

Efficacy
9.2

Fast and dramatic — one of the strongest results we measured.

Safety
4.6

Capped: isopropyl cloprostenate.

Ingredients
8.0

Amino acids, peptides and hyaluronic acid around the analogue.

Value
7.0

£65 for 2 ml, roughly two to three months of use.

The full review

12-week user trial · INCI read line by line

What is in it

A long list built mostly on amino acids — alanine, arginine, glycine, proline, threonine and the rest — with panthenol second and sodium hyaluronate for hydration. Twenty-fifth is isopropyl cloprostenate, which GrandeLASH-MD labels itself as "an analog of prostaglandin". Credit where it is due: the brand does not hide it. ICP is one of the three compounds the SCCS flagged in February 2026, and the analogue behind France's ANSES cosmetovigilance alert of December 2025 linking a lash serum to periorbital fat loss and iris darkening.

Full ingredient list

Water/Aqua/Eau, Panthenol, Glycerin, Sodium Citrate, Leuconostoc/Radish Root Ferment Filtrate, Alanine, Alcohol, Aloe Barbadensis Leaf Juice, Arctostaphylos Uva Ursi Leaf Extract, Arginine, Aspartic Acid, Calcium Gluconate, Caprylyl Glycol, Chamomilla Recutita Flower Extract, Ethylhexylglycerin, Gluconolactone, Glycine, Hexylene Glycol, Histidine, Honey Extract, Hydrolyzed Glycosaminoglycans, Hydrolyzed Yeast Extract, Hydroxyethylcellulose, Isoleucine, Isopropyl Cloprostenate (an analog of prostaglandin), Magnesium Ascorbyl Phosphate, Panax Ginseng Root Extract, PCA, Phenylalanine, Polysorbate 20, Proline, Propylene Glycol, Serine, Sodium Hyaluronate, Sodium Lactate, Sodium PCA, Threonine, Tocopheryl Acetate, Triethanolamine, Tussilago Farfara Leaf Extract, Valine, Vitis Vinifera Seed Extract, Phenoxyethanol, Sodium Benzoate, Sodium Metabisulfite.

How it performed

Among the fastest in the ranking. Visible length for most testers by week six, and by week twelve the results were second only to QUALASH. Three testers reported stinging on application in the first weeks. No pigmentation change was recorded in twelve weeks.

Who it is for

People who want maximum speed from a well-known brand and have read the ANSES and SCCS material. Avoid entirely with glaucoma, ocular hypertension, prescribed eye drops, pregnancy or breastfeeding, and think hard if you have light-coloured irises.

What we liked

✓
Among the fastest results in the ranking
✓
Well-supported base formula
✓
Widely stocked and easy to find

Keep in mind

−
Isopropyl cloprostenate — the most scrutinised analogue in the category
−
£65 for 2 ml
−
Stinging reported by several testers
The verdict

Ranked #8 of 15

Highly effective and the product we would most want someone to read the safety section before buying. If speed is everything, it delivers. If you have light irises, it is the one we would steer you away from first.

7.6
Growth score

Safety note

This product contains Isopropyl Cloprostenate. Prostaglandin analogues are associated with darkening of the eyelid skin, loss of fat around the eye socket and, rarely, permanent change to iris colour. Do not start it if you have glaucoma or ocular hypertension, or use prescribed eye drops, without speaking to a clinician. Patch-test first, photograph your eyes for a baseline, and stop if you notice redness, swelling, darkening or any change to your vision.

We review products, we are not clinicians, and this is not medical advice. Ingredient information was taken from the manufacturer's published INCI list on 13 August 2026 — formulas change and brands sell variants under similar names, so check the pack you are holding. If this page is out of date, email us and we will correct it.